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In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH)

312 Furthermore, endothelial cells respond to hyperuricemia by upregulating angiotensin-converting enzyme activity, which enhances angiotensin II and superoxide anion production

Before starting B12 injections, its important to consult with a healthcare provider to ensure that B12 deficiency is the underlying cause of your fatigue and to determine the right dosage for your needs